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ORIGINAL EVIDENCE.

PMID 3066983 ↗: placebo comparison during simulated spaceflight and 56-hour continuous work. Reported task results: tracking quality +10%, pursuit errors 1.8-fold lower, visual-detection time 2.4-fold shorter. Historical indexed abstract reviewed; sample size and allocation details unavailable.

The recovered 1991 paper describes 298 maritime operators with detailed testing in a 20-person subset. Reported static-effort endurance increased 13.7% in treated sailors. The recovered 2019 monograph describes a double-blind 78-volunteer workload experiment. Source format, subset size and allocation limitations remain explicit.

Human research also includes a 130-patient asthenia comparison, adjunctive infection and lupus reports, combination studies and exposure measurements. These settings supply context. They do not establish modern efficacy for the Antaeus indication. The dedicated review links every report directly.

RU2704126C2 Table 2 reports 41.66 minutes with Bemitil and 56.23 with a chlodantane formulation, versus 27.69 in controls. Calculated increases are 50.5% and 103.1%. Different doses and formulation effects limit comparisons. Bemitil group size is inconsistent in the text.

Antonova et al. 2023: 104 patients, 38 Dalargin / 66 controls. ARDS 5.3% / 21.2%; mortality did not differ significantly. Full-text methods do not report randomization or blinding. Restrictive exclusions and prolonged hospital infusion limit field translation.

PMID 2717231 ↗ reports reduced survival in a rat traumatic-shock model. PMID 7602944 ↗ reports benefit with reinfusion in a rabbit model. PMID 9622035 ↗ shows delivery can change Dalargin brain exposure and central effects. These are development risks to test directly.

The May 2026 MSMR report records these 2025 case counts among U.S. active-component service members. Heat-stroke incidence increased 6.9% from 2024, while heat-exhaustion incidence fell 9.1%. We use the latest report rather than presenting the 2024 increase as the current trend.

Founder-built catalog connecting compounds to original sources and evidence gaps. Source records are not a count of independent trials or validated therapies.